N. Kabiri; S. Asgary; H. Madani; P. Mahzoni; P. Rahimi
Volume 25, Issue 1 , May 2009, , Pages 29-38
Abstract
Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals ...
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Hypercholesterolemia and oxidative stress increase serum total cholesterol and LDL-C cholesterol levels resulting in increased risk for development of atherosclerosis. Antioxidants play an important role in inhibiting and scavenging radicals thus could be other important measures to benefit individuals with the increased cardiovascular disease risk factors. This study was designed to investigate the effect of aerial parts of Hypericum perforatum L. andAmaranthus caudatus L. on the development of atherosclerosis in male hyperlipidemic rabbits. Twenty adult male rabbits were randomly divided into four groups of five and were fed for 60 days as follows: basic diet, high cholesterol, high cholesterol along withcombination Hypericum perforatumandAmaranthus caudatus(HA) extract (75mg/kg) and high cholesterol along with Lovastatin (10mg/kg). Blood samples were taken at the beginning, one month later and at the end of the study in order to measure their serum factors (cholesterol, LDL-C-C, HDL-C-C, TG). The fatty streak formation evaluated at the end of the study. The results showed that both the extract and lovastatin reduced significantly the levels of cholesterol, LDL-C-C, triglyceride and HDL-C-C) increased in comparison with high cholesterol group. Fatty streak formation in extract recipient group significantly decreasedin comparison with high cholesterol group with lovastatin. The result showed that HA significantly decreased TG, cholesterol and fatty streak formation in comparison with high cholesterol group and lovastatin. These findings suggest HA extract is more effective in decreasing the level of cardiovascular risk factors than Lovastatin in hypercholesterolemic rabbits.
N. Kabiri; S. Asgary; H. Madani; P. Rahimi
Volume 24, Issue 3 , November 2008, , Pages 304-312
Abstract
Cardiovascular diseases and atherosclerosis are the leading cause of mortality and morbidity around the world. Inflammation and coagulation are two important risk factors of cardiovascular disease. In this study, the effect of the concurrent hydroalcoholic extracts of Hypericum perforatumL. and Amaranthus ...
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Cardiovascular diseases and atherosclerosis are the leading cause of mortality and morbidity around the world. Inflammation and coagulation are two important risk factors of cardiovascular disease. In this study, the effect of the concurrent hydroalcoholic extracts of Hypericum perforatumL. and Amaranthus caudatus L. on inflammatory and coagulation factors in hypercholesterolemic rabbits was studied and its effect was compared with lovastatin. Twenty adult male Newzeland rabbits were randomly divided into four groups of five and were fed for 60 days as follows: basic diet, high cholesterol, high cholesterol along withcombination of Hypericum and Amaranth (HA) extract (75mg/kg) and high cholesterol along with Lovastatin (10mg/kg). Blood samples were taken at the beginning, one month later and at the end of the study in order to measure their serum factors. The result showed that both the extract and lovastatin reduced significantly CRP, white blood cell, fibrinogen and platelet. Therefore Hypericum and Amaranthus by decreasing inflammation and coagulation risk factor prevent atherosclerosis also results showed that above extract is more effective to decrease Cardiovascular risk factor than lovastatin.
S. Asgary; N. Kabiri; H. Madani; P. Mahzoni; P. Rahimi
Volume 24, Issue 3 , November 2008, , Pages 353-362
Abstract
In this study, anti atherosclerosis effect of aerial parts extract of Amaranthus caudatus L. on rabbits was studied. Twenty male New Zealand rabbits were randomly divided into four groups of five and were fed for 60 days as follows: standard diet, standard diet and cholesterol, standard diet and Amaranthus ...
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In this study, anti atherosclerosis effect of aerial parts extract of Amaranthus caudatus L. on rabbits was studied. Twenty male New Zealand rabbits were randomly divided into four groups of five and were fed for 60 days as follows: standard diet, standard diet and cholesterol, standard diet and Amaranthus caudatus extract (150 mg/kg daily), standard diet and Amaranthus caudatus extract (150 mg/kg daily) and cholesterol. Prior to the beginning of diets and at the 60th day of experiment, the biochemical factors were measured. The fatty streak formation was evaluated at the end of the study. Rabbits fed high cholesterol diet with Amaranthus Caudatus extract cholesterol, LDL-C, triglyceride, apo-lipoprotein B (apoB), CRP, atherogenic index (AI) significantly decreased and HDL-C and apo-lipoprotein A (apoA) increased compared to with high cholesterol group. Also lesion severity, in extract recipient group, significantly decreased. Amaranthus caudatus extract by decreasing serum lipoproteins and apo B, is one of the most important new risk factors of cardiovascular diseases and by decreasing inflammatory factors prevent atherosclerosis.
N. Ahmadi Mahmoodabadi; H. Madani; P. Mahzooni
Volume 24, Issue 2 , August 2008, , Pages 148-161
Abstract
Artichoke with the scientific name of Cynara scolymus is a plantfromCompositeae family. In this research, the effect of hydroalcoholic extract of artichoke on the changes of serum glucose, lipids and lipoproteins in alloxan monohydrate-induced diabetic rats was investigated. Also, the effect of extract ...
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Artichoke with the scientific name of Cynara scolymus is a plantfromCompositeae family. In this research, the effect of hydroalcoholic extract of artichoke on the changes of serum glucose, lipids and lipoproteins in alloxan monohydrate-induced diabetic rats was investigated. Also, the effect of extract on damaged pancreatic tissue was investigated and was compared with glybenclamide as a chemical drug. Twenty adult male rats, weighing 200-250 gr, were used in four groups of five each (control, diabetic, diabetic+glibenclamide, diabetic + artichoke extract). The first group (control), received serum physiology equal to injecting material volume. Second group (diabetic), received 120 mg/kgbw alloxan monohydrate. Third group (diabetic + glibenclamide) received 0/5 mg/kg bw glibenclamide in addition to the similar treatment with second group. Fourth group (diabetic + Cynara scolymus) at first, became diabetic by alloxan monohydrate injection, then they received 300 mg/kgbw hydroalcoholic plant extract. Prescribing materials in all groups was done as interaperitoneal injection (IP). The results from statistical analysis show that Cynara scolymus extract reduce significantly the rate of glucose, cholesterol, triglyceride, VLDL and LDL than diabetic group (P</0 05). Also, artichoke which decreased rate of glucose was similar to glybenclamide group, but comparing to control group, it has significant difference. The effect of this plant on other investigating factors was similar to glybenclamid and control groups (P>/0 05). The results of Histologic studies confirmed this part of research. On the base of histologic results, extract have a significant effect on increasing the size of pancreatic islets, number of islet cells and cell proliferation than diabetic group. This research suggested that hydroalcoholic extract of Cynara scolymus has a significant effect on decreasing the blood sugar, serum lipids and lipoproteins than diabetic rats. Also the effect of extract in repairing damaged pancreatic tissue was confirmed.
N. Jafari Dinani; S. Asgary; H. Madani; Gh. Naderi; P. Mahzoni
Volume 23, Issue 1 , May 2007, , Pages 1-12
Abstract
Atherosclerosis occurs principally in medium and large arteries and is a leading cause of cardiovascular disease. Epidemiologic study indicates that coronary heart disease and atherosclerosis is less in societies which use herbal medicines. Glycyrrhiza glabra is an herb of Papilionaceae family which ...
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Atherosclerosis occurs principally in medium and large arteries and is a leading cause of cardiovascular disease. Epidemiologic study indicates that coronary heart disease and atherosclerosis is less in societies which use herbal medicines. Glycyrrhiza glabra is an herb of Papilionaceae family which contains hypolipidemic compounds and flavonoids with high antioxidant properties. This study was conducted to determine the effect of Glycyrrhiza glabra extract on blood lipid levels and atherosclerosis in rabbits fed with high cholesterol diet. Fifteen male rabbits were randomly divided into three groups, normal diet group, highcholesterolemic control group (1% cholesterol) and high-cholesterol + Glycyrrhiza glabra group (50 mg/kg body weight every other day). The concentration of total cholesterol (TC), LDL cholesterol, triglycerides (TG) and HDL cholesterol were determined in rabbits in the beginning of experiment, and in the end of the first and second month of the study. In the end of the experimental period the rabbits were killed having overdose chloroform and their aortas were removed for assessing atherosclerotic plaques. Results showed that Glycyrrhiza glabra decreased TC, LDL and TG levels and increased HDL, significantly. The lesion atherosclerotic significantly reduced in high-cholesterol + Glycyrrhiza glabra group as compared to highcholesterolemic control group. It could be suggested that the Glycyrrhiza glabra extract can effectively prevent the progress of atherosclerosis and extensive studies are needed to investigate the effect of Glycyrrhiza glabra in prevention and treatment of atherosclerosis.
S. Asgary; H. Madani; P. Mahzoni; N. Jafari; Gh. Naderi
Volume 22, Issue 4 , February 2007, , Pages 303-314
Abstract
Coronary heart disease (CHD) is invariably the most frequent cause of death in most of the west countries. Atherosclerosis which is the most common risk factor for CHD caused by a gradual deposition of fats and lipids in muscular arteries. Many species of Artemisia from Compositeae family have hypolipidemic ...
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Coronary heart disease (CHD) is invariably the most frequent cause of death in most of the west countries. Atherosclerosis which is the most common risk factor for CHD caused by a gradual deposition of fats and lipids in muscular arteries. Many species of Artemisia from Compositeae family have hypolipidemic and antioxidative properties. The objective of this study was to determine the effect of Artemisia sieberi extract on blood lipids and development of atherosclerosis in rabbits fed by a high cholesterol diet. For this objective 15 male rabbits were randomly divided in three groups (normal diet, hypercholesterolemic diet (HCD) and HCD + 100 mg/kg body weight Artemisia sieberi extract). Total cholesterol (TC), LDL cholesterol, triglycerides (TG) and HDL cholesterol were measured before starting and after 1st and 2nd months of experimental period. After two months, rabbits were killed following chloroform over dose and their aortas were removed for assessment of atherosclerotic plaques. The results indicate that Artemisia sieberi significantly reduces the levels of TC, LDL, TG and TC/HDL and significantly increase the level of HDL. The atherosclerotic plaque formation was significantly reduced in Artemisia sieberi group as compared to the control hypercholesterolemic group.